Agenda Details

Learn more about sessions and presentations at the 25th Annual Meeting

Detailed Program

Intended and Unintended Roles of Viral Vector Heterogeneity in Gene Therapy (Organized by the Viral Gene Transfer Vectors Committee)

In this symposium, speakers will discuss the impact of natural, engineered, and unexpected variations in the genomes and proteins of viral vectors. Variations in the sequences and lengths of packaged vector genomes can be caused by error, by viral polymerases, or by inefficient or incomplete genome packaging. When viral capsids or envelope proteins are engineered for new variations or functions, these intended variations can also introduce new complexities in viral vector production and purification. The impact of each of these intended and unintended variations in viral vector preparation impacts the efficacy and safety of their use for gene therapy, for gene-based vaccines, for oncolytic virotherapy, and for CAR-T and stem cell therapy.

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