Agenda Details

Delivery of genetic therapies to the airway epithelium presents unique challenges for a long-lasting therapeutic for people with cystic fibrosis (CF). The CF lung is characterized by thick, sticky mucus that dehydrates due to the loss of functional cystic fibrosis transmembrane conductance regulator (CFTR) channels. Dehydration of the mucus and plugging of the airway lead to reduced lung function and restricted distribution of inhaled aerosolized vector. Systemic delivery likely requires engineered vector tropism and the capacity to navigate from the vasculature to the epithelium. This symposium will bring together leaders in the nanotechnology field to present and discuss novel technologies and strategies to deliver genetic therapies to the lung.