Agenda Details

Transfer RNAs (tRNA) play a critical role in decoding mRNAs into proteins. These small ~76-90 nt RNA molecules function as cellular couriers and bring a specific amino acid to the ribosome complex that corresponds to the intended mRNA codon. A growing body of evidence implicates that engineered tRNAs can be used as therapeutic molecules to suppress premature stop codons and insert functional amino acids. In addition, emerging data suggest a pathobiological role of fragmented tRNAs in human diseases. This session will cover a range of topics from genetics of tRNAs to their pathophysiology and therapeutic use.