Agenda Details

Learn more about sessions and presentations at the 26th Annual Meeting

Detailed Program

tRNAs: Biology, Pathophysiology, and Potential Therapeutic Applications

Transfer RNAs (tRNA) play a critical role in decoding mRNAs into proteins. These small ~76-90 nt RNA molecules function as cellular couriers and bring a specific amino acid to the ribosome complex that corresponds to the intended mRNA codon. A growing body of evidence implicates that engineered tRNAs can be used as therapeutic molecules to suppress premature stop codons and insert functional amino acids. In addition, emerging data suggest a pathobiological role of fragmented tRNAs in human diseases. This session will cover a range of topics from genetics of tRNAs to their pathophysiology and therapeutic use.

Session Details


Mark A.. Kay, MD, PhD. Stanford University School of Medicine, Stanford, CA


Paloma H.. Giangrande, PhD. Wave Life Sciences, Cambridge, MA


Shen Shen, PhD. Vertex Pharmaceuticals, Boston, MA


Janaiah Kota. Ultragenyx, IN

Overview of genomic arrangements of tRNAs

Todd M. Lowe, PhD. University of California Santa Cruz, CA

tRNA derived small RNAs

Saumya Das, MD, PhD. Massachusetts General Hospital, Boston, MA

Therapeutic applications of tRNAs

Theonie Anastassiadis. Alltrna, MA, Flagship Pioneering, MA

mRNA Spell-checking with tRNA to Read-through Premature Termination Codons

Christopher Ahern, PhD. University of Iowa, IA

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