Agenda Details

Learn more about sessions and presentations at the 26th Annual Meeting

Detailed Program

tRNAs: Biology, Pathophysiology, and Potential Therapeutic Applications

Transfer RNAs (tRNA) play a critical role in decoding mRNAs into proteins. These small ~76-90 nt RNA molecules function as cellular couriers and bring a specific amino acid to the ribosome complex that corresponds to the intended mRNA codon. A growing body of evidence implicates that engineered tRNAs can be used as therapeutic molecules to suppress premature stop codons and insert functional amino acids. In addition, emerging data suggest a pathobiological role of fragmented tRNAs in human diseases. This session will cover a range of topics from genetics of tRNAs to their pathophysiology and therapeutic use.

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